Contrast enhancement of brain tumors and irradiated normal brain: a comparison of iohexol and iothalamate

The nonionic contrast agent iohexol was compared with the ionic agent iothalamate for contrast enhancement of brain tumors and radiation brain damage in dogs. Tissue enhancement during infusion of contrast and 5, 10, 15 and 30 min later was measured using quantitative computed tomography. Blood iodi...

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Bibliographic Details
Published in:Neuroradiology 1986-01, Vol.28 (1), p.61-64
Main Authors: FIKE, J. R, CANN, C. E, TUROWSKI, K, NORMAN, D, AX, L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - radiation effects
Brain Neoplasms - diagnostic imaging
Contrast media. Radiopharmaceuticals
Dogs
Ependymoma - diagnostic imaging
Iodine Radioisotopes - adverse effects
Iodobenzoates
Iohexol
Iothalamate Meglumine
Iothalamic Acid
Male
Medical sciences
Meningeal Neoplasms - diagnostic imaging
Meningioma - diagnostic imaging
Pharmacology. Drug treatments
Radiation Injuries, Experimental - diagnostic imaging
Tomography, X-Ray Computed
Triiodobenzoic Acids
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Summary:The nonionic contrast agent iohexol was compared with the ionic agent iothalamate for contrast enhancement of brain tumors and radiation brain damage in dogs. Tissue enhancement during infusion of contrast and 5, 10, 15 and 30 min later was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during infusion in tumors and after 5 min in irradiated normal brain for both contrast agents. Absolute uptake of contrast in each lesion was the same for both agents when normalized to total grams of iodine administered. Blood iodine levels were slightly but not significantly higher using iohexol. The reduced osmotic load and similar contrast enhancement of lesions suggest that the nonionic contrast medium iohexol may be a useful agent for routine CT of the brain.
ISSN:0028-3940
1432-1920
DOI:10.1007/BF00341768