Hyperaminoacidemia in epileptic children treated with valproic acid

Serum amino acids were determined in 22 epileptic children treated with valproic acid. This treatment caused hypocarnitinemia in all, and hyperammonemia in 16. Regardless of the blood ammonia levels, values for glutamic acid, arginine, glycine, serine and alanine were higher than those of normal con...

Full description

Saved in:
Bibliographic Details
Published in:Child's nervous system 1990-12, Vol.6 (8), p.434-436
Main Authors: CASTRO-GAGO, M, RODRIGO-SAEZ, E, NOVO-RODRIGUEZ, I, CAMINA, M. F, RODRIGUEZ-SEGADE, S
Format: Article
Language:English
Subjects:
Adolescent
Amino Acids - blood
Ammonia - blood
Biological and medical sciences
Child
Child, Preschool
Drug toxicity and drugs side effects treatment
Epilepsy - blood
Epilepsy - drug therapy
Humans
Infant
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Valproic Acid - adverse effects
Valproic Acid - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Serum amino acids were determined in 22 epileptic children treated with valproic acid. This treatment caused hypocarnitinemia in all, and hyperammonemia in 16. Regardless of the blood ammonia levels, values for glutamic acid, arginine, glycine, serine and alanine were higher than those of normal controls, while aspartic acid and ornithine were lower. These findings suggest that valproate causes intramitochondrial dysfunction of the urea cycle.
ISSN:0256-7040
1433-0350
DOI:10.1007/BF00302087