Shifts in auditory brainstem response latencies following plasma-level-controlled aminoglycoside therapy

The ototoxic effect of plasma-level-controlled netilmicin and tobramycin was monitored in 20 intensive care patients, using auditory brainstem responses (ABRs). ABRs were recorded at the onset and after 6 days of treatment. Significant shifts in the ABR wave V latency were observed independent of th...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 1990-06, Vol.247 (4), p.202
Main Authors: Hotz, M A, Allum, J H, Kaufmann, G, Follath, F, Pfaltz, C R
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - blood
Audiometry, Evoked Response
Evoked Potentials, Auditory - drug effects
Female
Humans
Intensive Care Units
Male
Netilmicin - adverse effects
Netilmicin - blood
Time Factors
Tobramycin - adverse effects
Tobramycin - blood
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Summary:The ototoxic effect of plasma-level-controlled netilmicin and tobramycin was monitored in 20 intensive care patients, using auditory brainstem responses (ABRs). ABRs were recorded at the onset and after 6 days of treatment. Significant shifts in the ABR wave V latency were observed independent of the type of medication received or whether the patients were intubated or not. Shifts were also observed in wave I latencies. These latter changes were only significant for the complete population, probably because this potential is more difficult to elicit and measure than is wave V. The I-V interlatency time was greater for netilmicin than for tobramycin. These results indicate that the cumulative effects of aminoglycoside ototoxicity may be different for the central and peripheral nervous systems, and therefore ABR measurements may be the most accurate way of controlling ototoxicity in intensive care patients.
ISSN:0937-4477
1434-4726
DOI:10.1007/BF00178984