Radioimmunotherapy with Iodine-131 Tositumomab in Patients with Low-Grade Non-Hodgkin's B-Cell Lymphoma Does Not Induce Loss of Acquired Humoral Immunity against Common Antigens

Thirty-one previously untreated patients with follicular low-grade B-cell non-Hodgkin's lymphoma expressing the CD20 antigen were treated with iodine-131 tositumomab therapy between 1996 and 1998. The therapy led to a temporary depletion of peripheral blood B-lymphocytes. Recovery of B-cells oc...

Full description

Saved in:
Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2001-07, Vol.100 (1), p.40-48
Main Authors: Nordøy, T., Kolstad, A., Tuck, M.K., Aaberge, I.S., Husebekk, A., Kaminski, M.S.
Format: Article
Language:English
Subjects:
Adult
Aged
anti-CD20
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antibody Formation - drug effects
Antibody Formation - radiation effects
Antigens, Bacterial - immunology
Antigens, CD20 - immunology
Antigens, Neoplasm - immunology
Antigens, Viral - immunology
Antineoplastic agents
B-cell lymphoma
Biological and medical sciences
Clostridium tetani - immunology
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Herpesvirus 3, Human - immunology
Humans
humoral immunity
Immunoglobulins - analysis
Immunologic Memory
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
iodine-131 tositumomab
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - therapy
Lymphoma, Follicular - immunology
Lymphoma, Follicular - therapy
Lymphoma, Non-Hodgkin - immunology
Lymphoma, Non-Hodgkin - therapy
Lymphopenia - etiology
Lymphopenia - immunology
Male
Measles virus - immunology
Medical sciences
Middle Aged
Mumps virus - immunology
Pharmacology. Drug treatments
Radioimmunotherapy
Rubella virus - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thirty-one previously untreated patients with follicular low-grade B-cell non-Hodgkin's lymphoma expressing the CD20 antigen were treated with iodine-131 tositumomab therapy between 1996 and 1998. The therapy led to a temporary depletion of peripheral blood B-lymphocytes. Recovery of B-cells occurred in most cases by 3 to 6 months and in all patients by 12 months posttherapy. A temporary decline in T-cell subpopulations, but no reduction in serum immunoglobulin levels, could be observed. ELISA techniques were used to detect specific antibodies against rubella, mumps, varicella zoster, measles, and tetanus. Almost all patients remained seropositive against the different antigens during the 1- to 2-year follow-up. No significant reduction in antibody concentrations to tetanus or measles could be detected. The data show that acquired humoral immunity against common antigens appears to be preserved despite a temporary loss of B-lymphocytes.
ISSN:1521-6616
1521-7035
DOI:10.1006/clim.2001.5050