Silver‐Iodide‐Catalyzed One‐Pot Three‐Component Synthesis of 3‐Amino Furans in Water

The readily available and inexpensive silver iodide catalyzed one‐pot three‐component reaction of 2‐ketoaldehdyes, secondary amines and terminal alkynes to access 3‐amino furans in environmentally benign water proceeds via tandem Mannich‐Grignard addition followed by intramolecular cyclization was d...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2020-06, Vol.5 (21), p.6242-6244
Main Authors: Kumar Rapeti, Siva, Chaitanya Kasina, Krishna, Gundepaka, Prasad, Birudaraju, Saritha, Sailaja B. B.
Format: Article
Language:English
Subjects:
Benign water medium
Catalysis
Cheap and readily available catalyst
One-pot synthesis
Sustainable Chemistry
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Summary:The readily available and inexpensive silver iodide catalyzed one‐pot three‐component reaction of 2‐ketoaldehdyes, secondary amines and terminal alkynes to access 3‐amino furans in environmentally benign water proceeds via tandem Mannich‐Grignard addition followed by intramolecular cyclization was described for the first time. We herein, first time reported the easily accessible as well as inexpensive silver iodide promoted one‐pot three‐component reaction of 2‐ketoaldehdyes, secondary amines and terminal alkynes for the synthesis of 3‐amino furans in moderate to high yields in environmentally benign water medium that proceeds through the tandem Mannich‐Grignard addition followed by intramolecular cyclization. In addition, the efforts are under growth for the expansion of substrate scope.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202001157