Antibacterial Nanoparticles Based on Fluorescent 3‐Substituted Uridine Analogue

With a sudden and rapid increase in the spread of antimicrobial resistance, there is an urgent need for the development of novel antimicrobial therapies. Nanoparticles with antimicrobial activity provide advantages such as improved solubility, permeability, stability and selectivity. In this study,...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2017-01, Vol.2 (1), p.557-561
Main Authors: Reddy, E. Ramanjaneya, Yaseen, Abdul M, Rizvi, Arshad, Deora, Girdhar S., Banerjee, Sharmistha, Sevilimedu, Aarti, Rajadurai, Marina
Format: Article
Language:English
Subjects:
antibacterial
fluorescence
nanoparticles
nucleoside
selectivity
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Summary:With a sudden and rapid increase in the spread of antimicrobial resistance, there is an urgent need for the development of novel antimicrobial therapies. Nanoparticles with antimicrobial activity provide advantages such as improved solubility, permeability, stability and selectivity. In this study, a uridine‐scaffold was connected to a pyrene fluorescent unit to obtain novel compound UPy via an economical and straightforward route. Further, fluorescent organic nanoparticles (FONs) were prepared via self assembly of UPy and were found to have antibacterial activity towards Gram positive bacteria. The fluorescent nature of the FONs allowed us to identify a binding partner and propose mechanism of action in vivo. We believe that UPy can be an excellent starting point for the development of novel, potent and selective antimicrobial nanotherapeutics. Fluorescent organic nanoparticles (FONs) were prepared from nucleoside (uridine)‐based fluorescent derivative and were found to have antibacterial activity towards Gram positive bacteria. The fluorescent nature of the FONs allowed us to identify a binding partner and propose mechanism of action in vivo.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201601708