123 I‐ m IBG scintigraphy in patients with known or suspected neuroblastoma: Results from a prospective multicenter trial

Abstract Background A prospective trial was conducted to confirm the diagnostic performance of 123 I‐ m IBG scintigraphy in patients with known or suspected neuroblastoma. Procedure One hundred patients (mean age 4.7 years) were enrolled, 86 with a previous diagnosis of neuroblastoma, 13 with suspec...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric blood & cancer 2009-07, Vol.52 (7), p.784-790
Main Authors: Vik, Terry A., Pfluger, Thomas, Kadota, Richard, Castel, Victoria, Tulchinsky, Mark, Farto, J.C. Alonso, Heiba, Sherif, Serafini, Aldo, Tumeh, Sabah, Khutoryansky, Natalie, Jacobson, Arnold F.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background A prospective trial was conducted to confirm the diagnostic performance of 123 I‐ m IBG scintigraphy in patients with known or suspected neuroblastoma. Procedure One hundred patients (mean age 4.7 years) were enrolled, 86 with a previous diagnosis of neuroblastoma, 13 with suspected disease based upon symptoms, imaging findings, and elevated catecholamines, and one adult with an abdominal tumor thought to be of neuroendocrine origin. All patients underwent whole‐body planar imaging 24 hr following IV administration of 1–10 mCi (37–370 MBq) 123 I‐ m IBG. SPECT imaging of the thorax/abdomen/pelvis was performed in 51 patients. Images were interpreted by three blinded readers, with consensus requiring agreement of at least two readers. Disease status was confirmed by histopathology, imaging results, catecholamine measurements, and follow‐up. Results Sixty‐four patients had active disease, 30 were without disease, and 6 were judged indeterminate because of insufficient confirmatory data. 123 I‐ m IBG scintigraphy had a sensitivity of 88% (56/64) and specificity of 83% (25/30). Sensitivity was 91% (30/33) among the subset of subjects who had both planar and SPECT imaging. Among 53 patients with recent histopathology, sensitivity and specificity were 93% and 92%, respectively. Most false‐negative interpretations were in patients with minimal residual disease (n = 4), while false‐positive interpretations generally involved atypical adrenal or other physiological uptake (n = 4). Conclusions This prospective multicenter trial of 123 I‐ m IBG scintigraphy documents high sensitivity and specificity of this imaging technique in patients with both newly diagnosed and previously treated neuroblastoma. Pediatr Blood Cancer 2009;52:784–790. © 2009 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.21932