Accurate mass measurements by Fourier transform mass spectrometry

The capability for accurate mass measurements is an important attribute of Fourier transform mass spectrometry (FTMS). Unlike other instrumental methods in mass spectrometry, FTMS still offers significant opportunities to improve mass measurement accuracy (MMA), making it an area of research. This r...

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Bibliographic Details
Published in:Mass spectrometry reviews 2005-03, Vol.24 (2), p.286-309
Main Authors: Zhang, Li-Kang, Rempel, Don, Pramanik, Birendra N., Gross, Michael L.
Format: Article
Language:English
Subjects:
accurate (exact) mass measurement
Analytical biochemistry: general aspects, technics, instrumentation
Analytical, structural and metabolic biochemistry
Applied sciences
Biological and medical sciences
Coulombic effects
electrospray ionization
Exact sciences and technology
Fourier transform (ion cyclotron resonance) mass spectrometry
Fundamental and applied biological sciences. Psychology
MALDI
mass calibration
Organic polymers
Physicochemistry of polymers
Properties and characterization
space-charge (Coulombic) effects
Structure, morphology and analysis
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Summary:The capability for accurate mass measurements is an important attribute of Fourier transform mass spectrometry (FTMS). Unlike other instrumental methods in mass spectrometry, FTMS still offers significant opportunities to improve mass measurement accuracy (MMA), making it an area of research. This review covers the published literature in FTMS from the late 1970s to the present. We discuss the development and evolution of mass calibration that give accuracies in the low ppm range. We sketch the derivation and show the common foundation of these mass calibration procedures. We also describe the relation of mass calibration and the fundamentals of ion motion and space‐charge effects, and we review efforts to improve the basic calibration procedure particularly those that correct for effects of space charge. The advent of matrix‐assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) have opened the door for FTMS to be used for analyzing at high performance biopolymers, including proteins, oligodeoxynucleotides (ODNs), oligosaccharides, and synthetic polymers. We also discuss the utility of FTMS for accurate mass measurement in these areas and some practical ways to improve MMA. © 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:286–309, 2005
ISSN:0277-7037
1098-2787
DOI:10.1002/mas.20013