Treatment of renal dysfunction after orthotopic liver transplantation: Options and outcomes

Chronic nephrotoxicity is one of the most serious side‐effects of calcineurin inhibitor treatment and a factor in mortality and morbidity after liver transplantation. In our transplant centre, among patients who underwent a liver transplantation between January 1989 and December 2000, 14 liver graft...

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Bibliographic Details
Published in:Liver transplantation 2003-07, Vol.9 (7), p.778-779
Main Author: Gonwa, Thomas A.
Format: Article
Language:English
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Summary:Chronic nephrotoxicity is one of the most serious side‐effects of calcineurin inhibitor treatment and a factor in mortality and morbidity after liver transplantation. In our transplant centre, among patients who underwent a liver transplantation between January 1989 and December 2000, 14 liver graft recipients (6.86%) developed de novo severe renal dysfunction as defined by a serum creatinine concentration above 200 micromol/L. Renal biopsy was performed in nine cases and evidenced histological lesions compatible with chronic nephrotoxicity related to calcineurin inhibitor treatment. For nine patients, we report the results of a prospective non‐randomized study consisting of cyclosporine or tacrolimus withdrawal associated with administration of mycophenolate mofetil or azathioprine. Despite this therapeutic modification, we did not observe a significant renal function improvement but on the other hand, there was no graft rejection. (Clin Transplant 2002;16:368‐373.)
ISSN:1527-6465
1527-6473
DOI:10.1002/lt.500090722