Bisphosphonate‐related osteonecrosis of the skull base

Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity. Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literature. We prese...

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Bibliographic Details
Published in:The Laryngoscope 2009-03, Vol.119 (3), p.449-452
Main Authors: Khan, Aayesha M., Sindwani, Raj
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Density Conservation Agents - adverse effects
Bone Density Conservation Agents - therapeutic use
Bones, joints and connective tissue. Antiinflammatory agents
Diagnosis, Differential
Diphosphonates - adverse effects
Diphosphonates - therapeutic use
Diseases of the osteoarticular system
Female
Follow-Up Studies
Humans
Imidazoles - adverse effects
Imidazoles - therapeutic use
Medical sciences
Middle Aged
Multiple Myeloma - drug therapy
Neurosurgical Procedures - methods
Osteonecrosis - chemically induced
Osteonecrosis - diagnostic imaging
Osteonecrosis - surgery
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Skull Base - diagnostic imaging
Skull Base - drug effects
Tomography, X-Ray Computed - methods
Vascular bone diseases
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Summary:Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity. Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literature. We present a unique case of extensive BRONJ involving the maxilla, sinuses, and skull base, complicated by sinusitis and an intracranial abscess. This is the first description of BRONJ involving the skull base. The pathogenesis and management of this process are reviewed. Laryngoscope, 119:449–452, 2009
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.20094