Palladium-catalyzed dehalogenation of 5-halopyrazoles

A new and efficient method for the dehalogenation of 5‐halopyrazoles was developed by using the catalytic amount of palladium (II) chloride and triphenylphosphine as a ligand at reflux under constant flow of hydrogen gas. The reaction gave the corresponding pyrazole products in good to excellent yie...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2012-01, Vol.49 (1), p.183-189
Main Authors: Chen, Chun-Yen, Huang, Yu-Ying, Su, Wei-Nien, Kaneko, Kimiyoshi, Kimura, Masayuki, Takayama, Hiroyuki, Wong, Fung Fuh
Format: Article
Language:English
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Summary:A new and efficient method for the dehalogenation of 5‐halopyrazoles was developed by using the catalytic amount of palladium (II) chloride and triphenylphosphine as a ligand at reflux under constant flow of hydrogen gas. The reaction gave the corresponding pyrazole products in good to excellent yields (≥83%). J. Heterocyclic Chem., (2012).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.845