Reactivity of p-phenyl substituted β-Enamino compounds using K-10/ultrasound. II. Synthesis of isoxazoles and 5-Isoxazolones

The condensation of 4‐phenyl substituted β‐enamino ketones 1a‐d and β‐enamino esters 5a‐d with hydroxylamine hydrochloride using K‐10 as the solid support under sonication was studied to evaluate the formation of isoxazole and 5‐isoxazolone rings from β‐enamino compounds with a substituted aromatic...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 1999-03, Vol.36 (2), p.505-508
Main Authors: Valduga, Claudete J., Santis, Denise B., Braibante, Hugo S., Braibante, Mara E. F.
Format: Article
Language:English
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Summary:The condensation of 4‐phenyl substituted β‐enamino ketones 1a‐d and β‐enamino esters 5a‐d with hydroxylamine hydrochloride using K‐10 as the solid support under sonication was studied to evaluate the formation of isoxazole and 5‐isoxazolone rings from β‐enamino compounds with a substituted aromatic ring. Isoxazoles 2a‐c, 3c‐d and 5‐isoxazolones 6a‐c and 7a‐d were obtained. The use of K‐10/ultrasound in this reaction furnished novel results in some cases.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570360229