Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: A possible mechanism of protection

Arabic gum (AG) is a naturally occurring compound that has been proposed to posses potent antioxidant activity. In this study, the possible effects whereby AG could protect against cardiotoxicity induced by doxorubicin (DOX) in mice were carried out. Administration of single dose of DOX (15 mg/kg, i...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2002, Vol.16 (5), p.254-259
Main Authors: Abd-Allah, Adel RA, Al-Majed, Abdulhakeem A., Mostafa, Adel M., Al-Shabanah, Othman A., Din, Ayman Gamal El, Nagi, Mahmoud N.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antineoplastic Agents - toxicity
Arabic Gum
Cardiotoxicity
Creatine Kinase
Creatine Kinase - blood
Doxorubicin - toxicity
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - pharmacology
Glutathione - metabolism
Gum Arabic - administration & dosage
Gum Arabic - pharmacology
Heart - drug effects
Injections, Intraperitoneal
Lipid Peroxidation
Lipid Peroxidation - drug effects
Lipid Peroxides - metabolism
Male
Malondialdehyde - analysis
Mice
Myocardium - metabolism
Reduced Glutathione
Superoxides - metabolism
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Summary:Arabic gum (AG) is a naturally occurring compound that has been proposed to posses potent antioxidant activity. In this study, the possible effects whereby AG could protect against cardiotoxicity induced by doxorubicin (DOX) in mice were carried out. Administration of single dose of DOX (15 mg/kg, i.p.) induced cardiotoxicity 72 h, manifested biochemically by a significant elevation of serum creatine kinase (CK) (EC 2.7.3.2). In addition, cardiotoxicity was further confirmed by the significant increase in lipid peroxides measured as malondialdehyde (MDA). Administration of AG (25 g/kg) orally for 5 days before and 72 h after DOX injection produced a significant protection against cardiotoxicity induced by DOX. This was evidenced by significant reductions in serum CK and cardiac lipid peroxides. The effect of AG was examined on the superoxide anion radical generated by enzymatic and nonenzymatic methods. The results indicate that AG is a potent superoxide scavenger. The superoxide scavenging effect of AG may explain, at least in part, the protective effect of AG against cardiotoxicity induced by DOX. © 2002 Wiley Periodicals, Inc. J Biochem Mol Toxicol 16:254–259, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10046
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.10046