TiO 2 -coated fluoride nanoparticles for dental multimodal optical imaging

Core-shell nanostructures associated with photonics techniques have found innumerous applications in diagnostics and therapy. In this work, we introduce a novel core-shell nanostructure design that serves as a multimodal optical imaging contrast agent for dental adhesion evaluation. This nanostructu...

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Bibliographic Details
Published in:Journal of biophotonics 2018-04, Vol.11 (4), p.e201700029
Main Authors: Braz, Ana K S, Moura, Diógenes S, Gomes, Anderson S L, Ohulchanskyy, Tymish Y, Chen, Guanying, Liu, Maixian, Damasco, Jossana, de Araujo, Renato E, Prasad, Paras N
Format: Article
Language:English
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Summary:Core-shell nanostructures associated with photonics techniques have found innumerous applications in diagnostics and therapy. In this work, we introduce a novel core-shell nanostructure design that serves as a multimodal optical imaging contrast agent for dental adhesion evaluation. This nanostructure consists of a rare-earth-doped (NaYF :Yb 60%, Tm 0.5%)/NaYF particle as the core (hexagonal prism, ~51 nm base side length) and the highly refractive TiO material as the shell (~thickness of 15 nm). We show that the TiO shell provides enhanced contrast for optical coherence tomography (OCT), while the rare-earth-doped core upconverts excitation light from 975 nm to an emission peaked at 800 nm for photoluminescence imaging. The OCT and the photoluminescence wide-field images of human tooth were demonstrated with this nanoparticle core-shell contrast agent. In addition, the described core-shell nanoparticles (CSNps) were dispersed in the primer of a commercially available dental bonding system, allowing clear identification of dental adhesive layers with OCT. We evaluated that the presence of the CSNp in the adhesive induced an enhancement of 67% scattering coefficient to significantly increase the OCT contrast. Moreover, our results highlight that the upconversion photoluminescence in the near-infrared spectrum region is suitable for image of deep dental tissue.
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201700029