Green tea constituent epigallocatechin‐3‐gallate selectively inhibits COX‐2 without affecting COX‐1 expression in human prostate carcinoma cells

Overexpression of cyclooxygenase (COX)‐2 has been implicated in many pathologic conditions, including cancer. One practical inference of this finding is that sustained inhibition of COX‐2 could serve as a promising target for prevention or therapy of cancer. Conventional nonsteroidal antiinflammator...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2005-02, Vol.113 (4), p.660-669
Main Authors: Hussain, Tajamul, Gupta, Sanjay, Adhami, Vaqar M., Mukhtar, Hasan
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
apoptosis
Apoptosis - drug effects
Arachidonic Acid - pharmacology
Biological and medical sciences
Catechin - analogs & derivatives
Catechin - therapeutic use
Cell Division - drug effects
cell growth
Cyclooxygenase 1
Cyclooxygenase 2
Dinoprostone - metabolism
epigallocatechin‐3‐gallate
General pharmacology
green tea
Humans
Isoenzymes - antagonists & inhibitors
Isoenzymes - genetics
Isoenzymes - metabolism
Male
Medical sciences
Membrane Proteins
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
prostaglandin E
Prostaglandin-Endoperoxide Synthases - genetics
Prostaglandin-Endoperoxide Synthases - metabolism
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tea
Tumor Cells, Cultured
Tumors
Urokinase-Type Plasminogen Activator - antagonists & inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Overexpression of cyclooxygenase (COX)‐2 has been implicated in many pathologic conditions, including cancer. One practical inference of this finding is that sustained inhibition of COX‐2 could serve as a promising target for prevention or therapy of cancer. Conventional nonsteroidal antiinflammatory drugs (NSAIDs) and recently developed COX‐2‐specific inhibitors have shown considerable promise in prevention of some forms of human cancer; however, its application is limited due to severe toxic side effects on normal cells. Therefore, there is a need to define novel, nontoxic dietary constituents with proven chemopreventive effects through other pathways that also possess COX‐2 but not COX‐1 inhibitory activity. Recent studies on green tea and its major polyphenolic constituent (‐)epigallocatechin‐3‐gallate (EGCG) have established its remarkable cancer preventive and some cancer therapeutic effects. Here, we show that EGCG inhibits COX‐2 without affecting COX‐1 expression at both the mRNA and protein levels, in androgen‐sensitive LNCaP and androgen‐insensitive PC‐3 human prostate carcinoma cells. Based on our study, it is tempting to suggest that a combination of EGCG with chemotherapeutic drugs could be an improved strategy for prevention and treatment of prostate cancer.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.20629