Electrochemical Sensing Platform Based on Graphene Oxide‐chitosan for Simultaneous Determination of some Antihypertensive Drugs

The development of selective and simple methods for the determination of different analytes is of great interest. This is the first time to show the applicability of graphene oxide‐chitosan (GO‐CS) nanocomposite for designing an electrochemical nanosensor for determination of Amlodipine, Valsartan,...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2023-01, Vol.35 (1), p.n/a
Main Authors: Nabizadeh, Hassan, Feyzi, Bahareh, Ahmad Salarian, Amir, Reza Abtahi, Seyed, Mohammadi, Ali, Hami, Zahra
Format: Article
Language:English
Subjects:
Amlodipine
and Valsartan
Graphene oxide/chitosan nanocomposite
Hydrochlorothiazide
Simultaneous detection
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Summary:The development of selective and simple methods for the determination of different analytes is of great interest. This is the first time to show the applicability of graphene oxide‐chitosan (GO‐CS) nanocomposite for designing an electrochemical nanosensor for determination of Amlodipine, Valsartan, and Hydrochlorothiazide, simultaneously. Differential pulse voltammetrics current of AML, HCT, and VAL increased linearly in the ranges of 0.1–110, 0.1–110, and 1–230 μM with LOD of 5.5×10−2, 3.5×10−2 and 8.6×10−2 μM, respectively. Finally, GO‐CS/GCE was used for the detection of these drugs in commercial tablets and compared with the reference method (HPLC).
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202200022