Preparation and Characterization of Bhant Leaves‐derived Nitrogen‐doped Carbon and its Use as an Electrocatalyst for Detecting Ketoconazole

In this study, the electrocatalytic characteristics of nitrogen‐doped carbon (NDC) prepared from Clerodendrum Infortunatum L leaves on a glassy carbon electrode (GCE) surface was evaluated with regards to its ability to detect the electroactive drug ketoconazole (KCZ). The NDC was prepared by carryi...

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Published in:Electroanalysis (New York, N.Y.) N.Y.), 2020-03, Vol.32 (3), p.528-535
Main Authors: Haque, Md. Aminul, Akanda, Md. Rajibul, Hossain, Delwar, Haque, M. Aminul, Buliyaminu, Ismail A., Basha, Shaik Inayath, Oyama, Munetaka, Aziz, Md. Abdul
Format: Article
Language:English
Subjects:
Bhant leaves
Electrochemical sensor
Glassy carbon electrode
Ketoconazole
Nitrogen-doped carbon
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Summary:In this study, the electrocatalytic characteristics of nitrogen‐doped carbon (NDC) prepared from Clerodendrum Infortunatum L leaves on a glassy carbon electrode (GCE) surface was evaluated with regards to its ability to detect the electroactive drug ketoconazole (KCZ). The NDC was prepared by carrying out a simple pyrolysis of dry powder of the leaves at 850 °C. The prepared NDC was characterized using field‐emission scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X‐ray photoelectron spectroscopy and Brunauer‐Emmett‐Teller analysis, and was then used as an electrode material. The performance of the electrochemical KCZ sensor with the NDC‐modified glassy carbon electrode (NDC/GCE) was found to be optimal when using PBS buffer at pH 3 and a concentration of 0.1 mg/ml of NDC in the conjugate with Nafion polymer. Under these conditions, the NDC/GCE displayed a KCZ detection limit of 3 μM and a linear dependence of its response on KCZ concentration over a wide range of KCZ concentrations from 47 μM to 752 μM (R2=0.9742). These results confirmed the potential of NDC as an electrocatalyst.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201900474