I 2 ‐Promoted Direct C−H Sulfenylation of Isoquinolin‐1(2 H )‐ones with Sulfonyl Chlorides

Abstract A simple, efficient, and green method for the iodine‐promoted regioselective C‐4 sulfenylation of isoquinolin‐1(2 H )‐ones using commercially available aryl sulfonyl chlorides as the sulfur source was described under metal‐ and solvent‐free conditions. The reaction proceeded smoothly under...

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Bibliographic Details
Published in:European journal of organic chemistry 2021-01, Vol.2021 (1), p.117-124
Main Authors: Yang, Cai‐Yun, Li, Xia, Liu, Bo, Huang, Guo‐Li
Format: Article
Language:English
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Summary:Abstract A simple, efficient, and green method for the iodine‐promoted regioselective C‐4 sulfenylation of isoquinolin‐1(2 H )‐ones using commercially available aryl sulfonyl chlorides as the sulfur source was described under metal‐ and solvent‐free conditions. The reaction proceeded smoothly under simple conditions to obtain 4‐arylthioisoquinolin‐1(2 H )‐ones in moderate to good yields, and showed high regioselectivity, broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving ArS . radicals as key intermediates is proposed for the present transformation.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202001371