Longitudinal analysis of Mycobacterium tuberculosis 19‐kDa antigen‐specific T cells in patients with pulmonary tuberculosis: association with disease activity and cross‐reactivity to a peptide from HIV env gp120

Abstract CD8 + T cells play a central role in immune protection against infection with Mycobacterium tuberculosis . One of the target epitopes for anti‐ M. tuberculosis directedCD8 + T cells is the HLA‐A2‐restricted 19‐kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope r...

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Published in:European journal of immunology 2003-06, Vol.33 (6), p.1613-1623
Main Authors: Höhn, Hanni, Kortsik, Cornelius, Tully, Glenn, Nilges, Katja, Necker, Antje, Freitag, Kirsten, Neukirch, Claudia, Galle, Peter, Löhr, Hans, Maeurer, Markus J.
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Language:English
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Summary:Abstract CD8 + T cells play a central role in immune protection against infection with Mycobacterium tuberculosis . One of the target epitopes for anti‐ M. tuberculosis directedCD8 + T cells is the HLA‐A2‐restricted 19‐kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV env gp120) protein characterized by IFN‐γ release. This cross‐reactivity was confirmed in ex vivo in M. tuberculosis 19‐kDa tetramer‐sorted T cells from patients with tuberculosis and in HIVgp120 tetramer‐reactive T cells sorted from HIV + patients. M. tuberculosis 19‐kDa antigen‐reactive T cells were present in HLA‐A2 + patients (10/10) with HIV infection with no evidence of M. tuberculosis infection, but they are absent in peripheral blood lymphocytes from healthy HLA‐A2 + individuals (10/10). M. tuberculosis 19‐kDa antigen‐reactive T cells were elevated in acute pulmonary tuberculosis, declined with response to therapy (7/10 patients) and resided in the terminally differentiated CD8 + T cell subset. CD8 + cross‐reactive T cells recognizing HIV env or M. tuberculosis 19‐kDa antigens may contribute to pathogenesis in individuals co‐infected with both pathogens and may also present a marker for active tuberculosis.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200323480