Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait

We performed a genomewide association study (GWAS) of primary erythrocyte thiopurine S‐methyltransferase (TPMT) activity in children with leukemia (n = 1,026). Adjusting for age and ancestry, TPMT was the only gene that reached genomewide significance (top hit rs1142345 or 719A>G; P = 8.6 × 10‐61...

Full description

Bibliographic Details

Published in:	Clinical pharmacology and therapeutics 2017-03, Vol.101 (3), p.373-381
Main Authors:	Liu, C, Yang, W, Pei, D, Cheng, C, Smith, C, Landier, W, Hageman, L, Chen, Y, Yang, JJ, Crews, KR, Kornegay, N, Karol, SE, Wong, FL, Jeha, S, Sandlund, JT, Ribeiro, RC, Rubnitz, JE, Metzger, ML, Pui, C‐H, Evans, WE, Bhatia, S, Relling, MV
Format:	Article
Language:	English
Subjects:	Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacokinetics Child Dose-Response Relationship, Drug Female Genome-Wide Association Study Genotype Humans Leukemia - drug therapy Male Mercaptopurine - administration & dosage Mercaptopurine - pharmacokinetics Methyltransferases - genetics Pharmacogenetics Polymorphism, Single Nucleotide
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!