Loading…
The risk of multiple primary breast and thyroid carcinomas: Role of the radiation dose
Abstract BACKGROUND Some studies have suggested that there is an association between breast carcinoma and thyroid carcinoma. Because ionizing radiation is a well known risk factor for breast and thyroid carcinomas, the authors studied the effect of the radiation dose delivered for the treatment of e...
Saved in:
| Published in: | Cancer 2003-09, Vol.98 (6), p.1309-1317 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract
BACKGROUND
Some studies have suggested that there is an association between breast carcinoma and thyroid carcinoma. Because ionizing radiation is a well known risk factor for breast and thyroid carcinomas, the authors studied the effect of the radiation dose delivered for the treatment of each of these two malignancies on the risk of subsequently developing the other malignancy.
METHODS
The risk of developing thyroid carcinoma subsequent to treatment for breast carcinoma was analyzed in 8 patients (cases) and 192 matched control patients (controls) nested in a cohort of 7711 women who were treated at Institut Gustave Roussy between 1954 and 1983. The risk of developing breast carcinoma after treatment for thyroid carcinoma was studied in a cohort of 2365 women who were treated in 3 French cancer centers between 1934 and 1995.
RESULTS
Six of 8 patients with breast carcinoma (75%) who developed thyroid carcinoma and 71% of patients in the control group received radiation therapy during their treatment. The median dose to the thyroid was 6.6 grays (Gy) in the case group and 9.4 Gy in the control group. The overall relative risk of thyroid carcinoma associated with radiation therapy was 1.2 (95% confidence interval, 0.2–6.2). No relation was observed between the radiation dose and the risk of thyroid carcinoma (
P
= 0.8). Among 2365 women who were treated for thyroid carcinoma, 48 women developed a subsequent breast carcinoma. A significant excess of breast carcinoma was observed among women younger than 59 years at the time of diagnosis of breast carcinoma compared with women in the same age group in the general population. The mean absorbed dose delivered to the breasts by
131
I and external radiation therapy was 0.7 Gy. No relation was found between the radiation dose and the risk of breast carcinoma (
P
= 0.8).
CONCLUSIONS
The previously reported excess incidence of breast carcinoma after thyroid carcinoma was not related to radiation treatment with
131
I and/or external radiation therapy. Radiation therapy for breast carcinoma did not increase the risk of subsequent thyroid carcinoma. Cancer 2003;98:1309–17. © 2003 American Cancer Society.
DOI 10.1002/cncr.11626
The previously reported excess incidence of breast carcinoma after thyroid carcinoma was not related to radiation treatment with
131
I and/or with external radiation therapy. Radiation therapy for breast carcinoma did not increase the risk of subsequent thyroid carcinoma. |
|---|---|
| ISSN: | 0008-543X 1097-0142 |
| DOI: | 10.1002/cncr.11626 |