Front Cover: Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo‐Organomagnesium Anilides (Chem. Eur. J. 9/2022)

Grignard reagents (R‐Mg‐X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least‐reactive electrophiles. A bulky magnesium anilide additive (in purple) generates a new organometallic reagent (R−Mg‐NHAr) in situ that boosts the n...

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Bibliographic Details
Published in:Chemistry : a European journal 2022-02, Vol.28 (9), p.n/a
Main Authors: Colas, Kilian, V. D. dos Santos, A. Catarina, Kohlhepp, Stefanie V., Mendoza, Abraham
Format: Article
Language:English
Subjects:
acylation
Grignard reaction
ketones
Magnesium
metalation
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Summary:Grignard reagents (R‐Mg‐X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least‐reactive electrophiles. A bulky magnesium anilide additive (in purple) generates a new organometallic reagent (R−Mg‐NHAr) in situ that boosts the nucleophilicity and selectivity of the organometallic ligand (in green). In the Research Article by A. Mendoza and co‐workers (DOI: 10.1002/chem.202104053), these reagents prove to be instrumental in the direct synthesis of ketones from carboxylic acids, a transformation that was only possible with some organolithium reagents before.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202200294