Synthesis of Novel Benazepril‐Derived Trizole Compounds Assisted by Ultrasound: In Vitro and In Silico Analysis for Potential Anticancer Properties

Abstract Benazepril‐based novel trizole derivatives are being explored as potential anticancer agents, designed with an N‐substituted 1,2,3‐triazole moiety linked to Benazepril's N‐1 position via a methylene bridge. An ultrasound irradiated CuAAC method was used to prepare all these compounds a...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-09
Main Authors: Ettam, Ashok, Rao, L. Vaikunta, Balakishan, Guniganti, Kancha, Rama Krishna, Mullaguri, Sai Chairitha, Kumar, K. Shiva
Format: Article
Language:English
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Summary:Abstract Benazepril‐based novel trizole derivatives are being explored as potential anticancer agents, designed with an N‐substituted 1,2,3‐triazole moiety linked to Benazepril's N‐1 position via a methylene bridge. An ultrasound irradiated CuAAC method was used to prepare all these compounds and evaluated their anti‐proliferative activities against cancer and drug‐resistant cell lines. While some of these compounds demonstrated anti‐proliferative activity towards leukemic cancer cell line K562, two of them displayed complete inhibitory activity. Interestingly, the compounds 5n and 5o showed potent activity against imatinib‐resistant cell lines suggesting their promise to overcome cancer drug resistance. Furthermore, molecular docking analysis revealed that compounds 5n and 5o have higher predicted sensitivity towards ACE protein when compared to benazepril and lisinopril indicating their value as potential drug lead molecules. This research introduces a distinctive approach by employing ultrasound to facilitate CuAAC reactions in medicinal chemistry.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202401235