Chiral recognition ability of oligopeptide derivatives consisting of glutamyl residues

The effect of the constituting amino acid residue [Glu(OBzl)] number on the chiral recognition ability was investigated. Chiral recognition sites were prepared from oligopeptide derivatives (constituting amino acid residue number = three–five) by adopting alternative molecular imprinting. It was mad...

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Bibliographic Details
Published in:Journal of applied polymer science 2005-03, Vol.95 (6), p.1302-1309
Main Authors: Yoshikawa, Masakazu, Nagai, Yasuharu, Moriguchi, Koji, Hiraoka, Satoshi
Format: Article
Language:English
Subjects:
Aminoacid polymers
Applied sciences
chiral
Exact sciences and technology
molecular imprinting
molecular recognition
peptides
Physicochemistry of polymers
selectivity
Synthetic biopolymers
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Summary:The effect of the constituting amino acid residue [Glu(OBzl)] number on the chiral recognition ability was investigated. Chiral recognition sites were prepared from oligopeptide derivatives (constituting amino acid residue number = three–five) by adopting alternative molecular imprinting. It was made clear that with a constituting amino acid residue number of four, the tetrapeptide derivative of Glu(OBzl) is the best candidate material to generate a chiral recognition site among eight types of oligopeptide derivatives in the study. The affinity constant between Ac‐L‐Trp and a chiral recognition site ranged from 3.4 × 103 to 1.08 × 104 mol−1 dm3, depending on the number of Glu(OBzl) residues in an oligopeptide derivative. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 95: 1302–1309, 2005
ISSN:0021-8995
1097-4628
DOI:10.1002/app.21307