Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4'-substituted terpyridine

Eight novel Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’‐substituted terpyridine were synthesized and characterized by elemental analysis, UV, IR, NMR, electron paramagnetic resonance, high‐resolution mass spectrometry and molar conductivity measurements. The cytotoxicity of these complexes a...

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Bibliographic Details
Published in:Applied organometallic chemistry 2013-07, Vol.27 (7), p.373-379
Main Authors: Wang, Shuxiang, Chu, Wenhao, Wang, Yuechai, Liu, Siyuan, Zhang, Jinchao, Li, Shenghui, Wei, Haiying, Zhou, Guoqiang, Qin, Xinying
Format: Article
Language:English
Subjects:
4'-substituted terpyridine
Cu(II) and Zn(II) complexes
cytotoxicity
Pd(II)
Pt(II)
Pt(II), Pd(II), Cu(II) and Zn(II) complexes
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Summary:Eight novel Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’‐substituted terpyridine were synthesized and characterized by elemental analysis, UV, IR, NMR, electron paramagnetic resonance, high‐resolution mass spectrometry and molar conductivity measurements. The cytotoxicity of these complexes against HL‐60, BGC‐823, KB and Bel‐7402 cell lines was evaluated by MTT assay. All the complexes displayed cytotoxicity with low IC50 values (
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.2988