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An Organocopper(III) Fluoride Triggering C-CF 3 Bond Formation
Copper(III) fluorides are catalytically competent, yet elusive, intermediates in cross-coupling. The synthesis of [PPh ][Cu (CF ) F] (2), the first stable (isolable) Cu -F, was accomplished via chloride addition to [Cu (CF ) (py)] (1) yielding [PPh ][Cu (CF ) Cl(py)] (1⋅Cl), followed by treatment wi...
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Published in: | Angewandte Chemie International Edition 2024-03, Vol.63 (11), p.e202319412 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Copper(III) fluorides are catalytically competent, yet elusive, intermediates in cross-coupling. The synthesis of [PPh
][Cu
(CF
)
F] (2), the first stable (isolable) Cu
-F, was accomplished via chloride addition to [Cu
(CF
)
(py)] (1) yielding [PPh
][Cu
(CF
)
Cl(py)] (1⋅Cl), followed by treatment with AgF. The Cu
halides 1⋅Cl and 2 were fully characterized using nuclear magnetic resonance (NMR) spectroscopy, single crystal X-ray diffraction (Sc-XRD) and elemental analysis (EA). Complex 2 proved capable of forging C-CF
bonds from silyl-capped alkynes. In-depth mechanistic studies combining probes, theoretical calculations, trapping of intermediate 4
([PPh
][Cu
(CF
)
(C≡CPh)]) and radical tests unveil the key role of the Cu
acetylides that undergo facile 2e
reductive elimination furnishing the trifluoromethylated alkynes (RC≡CCF
), which are industrially relevant synthons in drug discovery, pharma and agrochemistry. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202319412 |