Inside Cover: Poly(2‐Oxazoline)‐Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance (Angew. Chem. Int. Ed. 16/2020)

Poly(2‐oxazoline)s (POXs) were employed as a new class of host defense peptide mimics. As reported by R. Liu and co‐workers in their Research Article on page 6412, these functional peptide mimics show potent in vitro and in vivo antimicrobial activity against methicillin‐resistant Staphylococcus aur...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-04, Vol.59 (16), p.6294-6294
Main Authors: Zhou, Min, Qian, Yuxin, Xie, Jiayang, Zhang, Wenjing, Jiang, Weinan, Xiao, Ximian, Chen, Sheng, Dai, Chengzhi, Cong, Zihao, Ji, Zhemin, Shao, Ning, Liu, Longqiang, Wu, Yuequn, Liu, Runhui
Format: Article
Language:English
Subjects:
antibiotics
antimicrobials
drug design
peptides
polymers
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Summary:Poly(2‐oxazoline)s (POXs) were employed as a new class of host defense peptide mimics. As reported by R. Liu and co‐workers in their Research Article on page 6412, these functional peptide mimics show potent in vitro and in vivo antimicrobial activity against methicillin‐resistant Staphylococcus aureus (MRSA) while alleviating antibiotic resistance and killing antibiotic‐tolerant MRSA persisters through a reactive oxygen species (ROS)‐dependent mechanism.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202003610