Astrocyte reactivity moderates the effect of education on cognitive reserve

Background Cognitive reserve and resilience account for differential susceptibility to brain aging and disease across individuals. Previous data suggest that functional connectivity among different brain areas is associated with cognitive reserve. However, its neural basis is yet unclear. In this st...

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Published in:Alzheimer's & dementia 2023-12, Vol.19 (S14), p.n/a
Main Authors: Borelli, Wyllians Vendramini, Antônio De Bastiani, Marco, Bieger, Andrei, Ferrari‐Souza, João Pedro, Castilhos, Raphael Machado, Rosa‐Neto, Pedro, Zimmer, Eduardo R.
Format: Article
Language:English
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Summary:Background Cognitive reserve and resilience account for differential susceptibility to brain aging and disease across individuals. Previous data suggest that functional connectivity among different brain areas is associated with cognitive reserve. However, its neural basis is yet unclear. In this study, we investigated the moderating effect of astrocyte reactivity in cognitive reserve. Method Cognitively unimpaired individuals who had plasma GFAP analyzed were selected from ADNI at baseline (n = 130). Years of education were used as a proxy of cognitive reserve; the Montreal Cognitive Assessment (MoCA) total score was retrieved from all individuals. A moderation analysis was performed according to the most recent framework for reserve and resilience in aging concepts. The total MoCA score was the outcome, and we investigated the moderation of plasma GFAP in the association of years of education and MoCA. Data are shown as mean+‐SD. Result A total of 130 individuals had complete data for all variables (72.3+‐6.3 years of age; 16.36+‐2.75 years of education; 43.1% females). A significant moderating effect was found in plasma GFAP and years of education (beta = 0.004, p = 0.0006) as a predictor of total MoCA scores (Model R2 = 0.37, p < 0.0001) when correcting for age and gender. Plasma GFAP and sex were also predictors of total MOCA scores independently (p
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.080034