Effects of meditation training and non‐native language training on cognition in older‐adults: A secondary analysis of the three‐arm Age‐Well randomized controlled trial

Background Non‐pharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults. We investigated the effects of 18‐months meditation or non‐native language training versus no intervention on cognition in older adults. Method Age‐Well was an observer...

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Published in:Alzheimer's & dementia 2023-12, Vol.19 (S23), p.n/a
Main Authors: Demnitz‐King, Harriet, Requier, Florence, Whitfield, Tim, Schlosser, Marco, Gonneaud, Julie, Ware, Caitlin, Barnhofer, Thorsten, Coll‐Padros, Nina, Dautricourt, Sophie, Delarue, Marion, Klimecki, Olga M, Paly, Léo, Salmon, Eric, Schild, Ann‐Katrin, Wirth, Miranka, Frison, Eric, Lutz, Antoine, Chetelat, Gael, Collette, Fabienne, Marchant, Natalie L
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Language:English
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Summary:Background Non‐pharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults. We investigated the effects of 18‐months meditation or non‐native language training versus no intervention on cognition in older adults. Method Age‐Well was an observer‐blind, randomised, controlled clinical trial with three parallel arms. Cognitively healthy adults aged ≥ 65 years and were recruited in France. Participants were randomised (1:1:1) to a meditation training, non‐native language (English) training, or a no intervention group for 18 months. Cognition (a pre‐specified secondary outcome) was assessed pre‐ and post‐intervention via the Preclinical Alzheimer’s Cognitive Composite 5 (PACC5), and composites assessing episodic memory, executive function, and attention. Linear mixed models, adjusted for age, sex, and education, evaluated cognitive changes between arms. Baseline neocortical amyloid deposition was added as a fixed effect in a sensitivity analysis. Additional sensitivity analyses assessed intervention effects for participants who attended at least 20% of intervention classes or were classified as ‘responders’. Results 137 participants were randomly assigned to meditation training (n = 45), non‐native language training (n = 46), or no intervention (n = 46). Two participants were excluded for not meeting eligibility criteria, and one died during follow‐up (Figure 1). A positive effect of non‐native language training was observed on episodic memory relative to the no intervention group (0·32 [95% CI: 0·04‐0·61], p = 0·025), and on PACC5 scores compared to meditation training (0·33 [95% CI: 0·01‐0·66], p = 0·045; Figure 2). In sensitivity analyses, neither the inclusion of amyloid as an additional covariate nor the exclusion of participants who attended
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.077759