Hippocampal connectivity in illiterate adults from Brazil

Background The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Methods Thirty‐nine illiterate adults underwent resting state functional MRI a...

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Bibliographic Details
Published in:Alzheimer's & dementia 2021-12, Vol.17 (S10), p.n/a
Main Authors: Resende, Elisa de Paula França, Rosen, Howard J, Friedlaender, Clarisse Vasconcelos, Lara, Vivian Proença, Santiago, Ana Luisa Carvalho, Silva, Lênio Lúcio Gávio, Brown, Jesse A, Maciel, Francisca, Grinberg, Lea T, Caramelli, Paulo
Format: Article
Language:English
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Summary:Background The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Methods Thirty‐nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test). We correlated the hippocampal connectivity at rest with the free recall scores. Analyzes were corrected for head motion and physiological BOLD signal. Results Participants were most female (66%) and black (79%) and the mean age was 49 years‐old (±13.9). The mean score on free recall was 27.2 (±10.7) out of 48 points. We found a significant correlation between the hippocampus and the right parahippocampal gyrus, right insula and right basal ganglia. However, we did not find an association between the hippocampal connectivity and the memory scores. Conclusions Illiterate adults have a significant correlation between the hippocampus and the right insula and basal ganglia. The lack of association with memory scores might be associated with low brain reserve in this group of individuals.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.051877