Multicomponent Synthesis of 5‐Cyano‐pyrazolo[1,5‐a]pyrimidines Enabled by Aerobic Manganese Catalysis

An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous repo...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-03, Vol.365 (6), p.871-876
Main Authors: Qu, Heng‐Tong, Wu, Zeng‐Hui, Zhong, Guo‐Chen, Zhang, Yan‐Chun, Feng, Cheng‐Tao, Xu, Kun
Format: Article
Language:English
Subjects:
Cyanation
Manganese catalysis
Multicomponent reaction
Strecker reaction
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Summary:An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, this mechanistically distinct protocol serves as a step‐economic, regioselective and functionally tolerant strategy to obtain 5‐cyano‐pyrazolo[1,5‐a]pyrimidines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202201361