APC Targeting: mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo (Adv. Healthcare Mater. 17/2018)

The study in article 1800335 by Salvador Borrós and co‐workers, takes advantage of the known versatile properties of the oligopeptide end‐modified poly (β‐amino esters) (OM‐PBAEs) to complex mRNA and form nanoparticles. It is demonstrated that the selection of the appropriate end‐oligopeptide modifi...

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Bibliographic Details
Published in:Advanced healthcare materials 2018-09, Vol.7 (17), p.n/a
Main Authors: Fornaguera, Cristina, Guerra‐Rebollo, Marta, Ángel Lázaro, Miguel, Castells‐Sala, Cristina, Meca‐Cortés, Oscar, Ramos‐Pérez, Victor, Cascante, Anna, Rubio, Núria, Blanco, Jerónimo, Borrós, Salvador
Format: Article
Language:English
Subjects:
antigen‐presenting cells transfection
immunotherapy
mRNA encapsulation and delivery
oligopeptide‐modified poly‐(β‐aminoester) polyplexes
spleen
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Summary:The study in article 1800335 by Salvador Borrós and co‐workers, takes advantage of the known versatile properties of the oligopeptide end‐modified poly (β‐amino esters) (OM‐PBAEs) to complex mRNA and form nanoparticles. It is demonstrated that the selection of the appropriate end‐oligopeptide modifications enables the specific targeting and major transfection of antigen‐presenting cells (APC) in vivo, after intravenous administered.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201870071