Vigorous exercise in patients with hypertrophic cardiomyopathy

We aimed to investigate if history of vigorous exercise was associated with changes in left ventricular morphology, left ventricular function and ventricular arrhythmias (VAs) in hypertrophic cardiomyopathy genotype positive, phenotype negative (Genotype+ LVH−) and in phenotype positive (HCM LVH+)....

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Bibliographic Details
Published in:International journal of cardiology 2018-01, Vol.250, p.157-163
Main Authors: Dejgaard, Lars A., Haland, Trine F., Lie, Oyvind H., Ribe, Margareth, Bjune, Thea, Leren, Ida Skrinde, Berge, Knut Erik, Edvardsen, Thor, Haugaa, Kristina H.
Format: Article
Language:eng ; nor
Subjects:
Adult
Aged
Arrhythmias
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - physiopathology
Cross-Sectional Studies
Echocardiography - methods
Exercise
Exercise - physiology
Female
Genetics
Heart Ventricles - diagnostic imaging
Humans
Hypertrophic cardiomyopathy
Magnetic Resonance Imaging, Cine - methods
Male
Middle Aged
Retrospective Studies
Surveys and Questionnaires
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Summary:We aimed to investigate if history of vigorous exercise was associated with changes in left ventricular morphology, left ventricular function and ventricular arrhythmias (VAs) in hypertrophic cardiomyopathy genotype positive, phenotype negative (Genotype+ LVH−) and in phenotype positive (HCM LVH+). In this cross sectional study we included 187 subjects (age 49±16years, 89(48%) female, 121(65%) HCM LVH+ and 66 (35%) Genotype+ LVH-) who answered a questionnaire on physical activity history. Exercise ≥6 metabolic equivalents was defined as vigorous. Subjects with a history of vigorous exercise ≥4h/week during ≥6years were defined as athletes. All underwent echocardiography and Holter monitoring. VAs were defined as aborted cardiac arrest, sustained or non-sustained ventricular tachycardia. In both Genotype+ LVH− and HCM LVH+, lifetime vigorous exercise correlated with larger left ventricular end-diastolic volume (rho 0.44 and 0.38 respectively, both p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2017.07.015