Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism

Background High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk i...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2023
Main Authors: Hansen, Ellen-Sofie, Edvardsen, Magnus, Aukrust, Pål, Ueland, Thor, Hansen, John Bjarne, Brækkan, Sigrid Kufaas, Morelli, Vania Maris
Format: Article
Language:Norwegian
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Summary:Background High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown. Objectives We aimed to investigate the joint effect of high FVIII levels and large platelets, as reflected by high MPV, on the risk of future incident VTE. Methods A population-based nested case-control study with 365 incident VTE cases and 710 controls was derived from the Tromsø study. FVIII antigen levels and MPV were measured in blood samples drawn at baseline. Odds ratios with 95% CIs were estimated across FVIII tertiles (
ISSN:1538-7933
1538-7836