LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients: A sex and gender-specific analysis

Despite lipid lowering therapy (LLT), reaching LDL-C targets in patients with familial hypercholesterolemia (FH) remains challenging. Our aim was to determine attainment of LDL-C target levels and reasons for not reaching these in female and male FH patients. We performed a cross-sectional study of...

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Bibliographic Details
Published in:Atherosclerosis 2023-11, Vol.384, p.117117-117117, Article 117117
Main Authors: Schreuder, M.M., Hamkour, S., Siegers, K.E., Holven, K.B., Johansen, A.K., van de Ree, M.A., Imholz, B., Boersma, E., Louters, L., Bogsrud, M.P., Retterstøl, K., Visseren, F.L.J., Roeters van Lennep, J.E., Koopal, C.
Format: Article
Language:English
Subjects:
Familial hypercholesterolemia
LDL-Cholesterol
Lipid-lowering therapy
PCSK9 monoclonal antibody
Statin
Treatment target
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Summary:Despite lipid lowering therapy (LLT), reaching LDL-C targets in patients with familial hypercholesterolemia (FH) remains challenging. Our aim was to determine attainment of LDL-C target levels and reasons for not reaching these in female and male FH patients. We performed a cross-sectional study of heterozygous FH patients in five hospitals in the Netherlands and Norway. Clinical characteristics and information about LLT, lipid levels and reasons for not being on LDL-C treatment target were retrospectively collected from electronic medical records. We studied 3178 FH patients (53.9% women), median age 48.0 (IQR 34.0–59.9) years. Median LDL-C before treatment and on-treatment was higher in women compared to men (6.2 (IQR 5.1–7.3) and 6.0 (IQR 4.9–7.2) mmol/l (p=0.005) and 3.0 (IQR 2.4–3.8) and 2.8 (IQR 2.3–3.5) mmol/L (p
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2023.03.022