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Parental inflammatory bowel disease and autism in children
Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based coho...
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Published in: | Nature medicine 2022-07, Vol.28 (7), p.1406-1411 |
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creator | Sadik, Aws Dardani, Christina Pagoni, Panagiota Havdahl, Alexandra Stergiakouli, Evie Khandaker, Golam M Sullivan, Sarah A Zammit, Stan Jones, Hannah J Davey Smith, George Dalman, Christina Karlsson, Håkan Gardner, Renee M Rai, Dheeraj |
description | Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated. |
doi_str_mv | 10.1038/s41591-022-01845-9 |
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We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated.</description><identifier>ISSN: 1078-8956</identifier><identifier>ISSN: 1546-170X</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/s41591-022-01845-9</identifier><identifier>PMID: 35654906</identifier><language>eng ; nor</language><publisher>United States: Nature Publishing Group</publisher><subject>Anemia ; Autism ; Autism Spectrum Disorder - genetics ; Autistic Disorder - epidemiology ; Autistic Disorder - genetics ; Child ; Children ; Cohort Studies ; Colitis, Ulcerative ; Correlation analysis ; Etiology ; Female ; Genotypes ; Humans ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - epidemiology ; Inflammatory Bowel Diseases - genetics ; Intestine ; Liability ; Linkage disequilibrium ; Longitudinal Studies ; Malabsorption ; Medicin och hälsovetenskap ; Parents ; Phenotypes ; Polygenic inheritance ; Population studies ; Pregnancy ; Risk analysis ; Ulcerative colitis</subject><ispartof>Nature medicine, 2022-07, Vol.28 (7), p.1406-1411</ispartof><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated.</description><subject>Anemia</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Autistic Disorder - epidemiology</subject><subject>Autistic Disorder - genetics</subject><subject>Child</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Colitis, Ulcerative</subject><subject>Correlation analysis</subject><subject>Etiology</subject><subject>Female</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - genetics</subject><subject>Intestine</subject><subject>Liability</subject><subject>Linkage disequilibrium</subject><subject>Longitudinal 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Spectrum Disorder Working Group</aucorp><aucorp>The iPSYCH Autism Spectrum Disorder Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parental inflammatory bowel disease and autism in children</atitle><jtitle>Nature medicine</jtitle><addtitle>Nat Med</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>28</volume><issue>7</issue><spage>1406</spage><epage>1411</epage><pages>1406-1411</pages><issn>1078-8956</issn><issn>1546-170X</issn><eissn>1546-170X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>NFR/274611</notes><abstract>Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. 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subjects | Anemia Autism Autism Spectrum Disorder - genetics Autistic Disorder - epidemiology Autistic Disorder - genetics Child Children Cohort Studies Colitis, Ulcerative Correlation analysis Etiology Female Genotypes Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - genetics Intestine Liability Linkage disequilibrium Longitudinal Studies Malabsorption Medicin och hälsovetenskap Parents Phenotypes Polygenic inheritance Population studies Pregnancy Risk analysis Ulcerative colitis |
title | Parental inflammatory bowel disease and autism in children |
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