Parental inflammatory bowel disease and autism in children

Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based coho...

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Bibliographic Details
Published in:Nature medicine 2022-07, Vol.28 (7), p.1406-1411
Main Authors: Sadik, Aws, Dardani, Christina, Pagoni, Panagiota, Havdahl, Alexandra, Stergiakouli, Evie, Khandaker, Golam M, Sullivan, Sarah A, Zammit, Stan, Jones, Hannah J, Davey Smith, George, Dalman, Christina, Karlsson, Håkan, Gardner, Renee M, Rai, Dheeraj
Format: Article
Language:eng ; nor
Subjects:
Anemia
Autism
Autism Spectrum Disorder - genetics
Autistic Disorder - epidemiology
Autistic Disorder - genetics
Child
Children
Cohort Studies
Colitis, Ulcerative
Correlation analysis
Etiology
Female
Genotypes
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - genetics
Intestine
Liability
Linkage disequilibrium
Longitudinal Studies
Malabsorption
Medicin och hälsovetenskap
Parents
Phenotypes
Polygenic inheritance
Population studies
Pregnancy
Risk analysis
Ulcerative colitis
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Summary:Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated.
ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/s41591-022-01845-9