Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test

Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when...

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Bibliographic Details
Published in:Acta dermato-venereologica 2012-01, Vol.92 (3), p.316-319
Main Authors: OVE HJELMEVOLL, Stig, ELISE OLSEN, Merethe, SOLLID, Johanna U. Ericson, HAAHEIM, Hakon, MELBY, Kjetil K, MOI, Harald, UNEMO, Magnus, SKOGEN, Vegard
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the genital system
Basale medisinske, odontologiske og veterinærmedisinske fag: 710
Basic medical, dental and veterinary science disciplines: 710
Biological and medical sciences
Cefixime - therapeutic use
Cervix Uteri - microbiology
Ciprofloxacin - therapeutic use
Dermatology
Drug Resistance, Bacterial
Epidemiology. Vaccinations
Female
General aspects
Gonorrhea - diagnosis
Gonorrhea - drug therapy
Human bacterial diseases
Humans
Infectious diseases
Male
Medical disciplines: 700
Medical microbiology: 715
Medical sciences
Medisinsk mikrobiologi: 715
Medisinske Fag: 700
Microbial Sensitivity Tests
Middle Aged
N. gonorrhoeae
NAAT
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - isolation & purification
Nucleic Acid Amplification Techniques
PCR
Pharynx - microbiology
Rectum - microbiology
test-of-cure
Time Factors
TOC
Urethra - microbiology
VDP
Young Adult
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Summary:Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg × 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive strains were resistant to ciprofloxacin. Thus, the recommended empirical treatment with ciprofloxacin in Norway should be changed immediately. TOC can be performed 2 weeks after treatment when NAATs are used for diagnosis of gonorrhoea.
ISSN:0001-5555
1651-2057
1651-2057
DOI:10.2340/00015555-1275