Characterization and prognostic value of lymphatic vessels in an oral tongue squamous cell carcinoma cohort

Tumor lymphangiogenesis increases the area of interaction between lymphatic vessels and tumor cells, and may thereby facilitate metastases. In oral cancer high lymphatic vessel density (LVD) and large lymphatic vessel area (LVA) have been associated with more aggressive tumors, but results from diff...

Full description

Saved in:
Bibliographic Details
Main Authors: Andersson Cronblad, Ida, Warvik, Cathrine Elise, Bjerkli, Inger-Heidi, Eriksson Steigen, Sonja, Uhlin-Hansen, Lars, Magnussen, Synnøve, Hadler-Olsen, Elin, Wirsing, Anna Maria
Format: Dissertation
Language:English
Subjects:
Basale medisinske, odontologiske og veterinærmedisinske fag: 710
Basic medical, dental and veterinary science disciplines: 710
Generell patologi, patologisk anatomi: 719
Klinisk odontologiske fag: 830
Medical disciplines: 700
Medical immunology: 716
Medisinsk immunologi: 716
Medisinske Fag: 700
Oral kirurgi: 835
Oral medisin: 835
VDP
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor lymphangiogenesis increases the area of interaction between lymphatic vessels and tumor cells, and may thereby facilitate metastases. In oral cancer high lymphatic vessel density (LVD) and large lymphatic vessel area (LVA) have been associated with more aggressive tumors, but results from different studies are not conclusive. The aim of this study was to assess the association of tumor-associated LVD and LVA with clinical-pathological data, including patient survival, in a homogenous cohort of oral tongue squamous cell carcinoma (OTSCC) patients. Formalin-fixed, paraffin-embedded tumour samples from 125 OTSCC patients were immunohistochemically stained with the D2-40 antibody to recognize lymphatic vessels. The mean LVD and the mean LVA were analysed in five hotspots per tumour sample and compared to clinical-pathological data as well as 5-year disease-specific survival (DSS). Neither LVD nor LVA were significantly associated with the clinical-pathological variables or 5-year DSS in our patient cohort. In univariate analyses, the N status, tumour stage, tumour differentiation as well as lymphocyte infiltration were the only significant predictors for patient outcome (p