ATG9A protects the plasma membrane from programmed and incidental permeabilization

The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show...

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Published in:	Nature cell biology 2021-08, Vol.23 (8), p.846-858
Main Authors:	Claude-Taupin, Aurore, Jia, Jingyue, Bhujabal, Zambarlal, Garfa-Traoré, Meriem, Kumar, Suresh, da Silva, Gustavo Peixoto Duarte, Javed, Ruheena, Gu, Yuexi, Allers, Lee, Peters, Ryan, Wang, Fulong, da Costa, Luciana Jesus, Pallikkuth, Sandeep, Lidke, Keith A, Mauthe, Mario, Verlhac, Pauline, Uchiyama, Yasuo, Salemi, Michelle, Phinney, Brett, Tooze, Sharon A, Mari, Muriel C, Johansen, Terje, Reggiori, Fulvio, Deretic, Vojo
Format:	Article
Language:	eng
Subjects:	Autophagosomes - metabolism Autophagy Autophagy (Cytology) Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Biology Cell Membrane - metabolism Cell membranes Cell research Cellular control mechanisms Coronaviruses Damage Genetic aspects Health sciences HEK293 Cells HeLa Cells Humans Immunoblotting Immunoprecipitation IQGAP1 protein Kinases Ligands Lipids Medical research Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Metabolism Microorganisms Microscopy Microscopy, Confocal Phagocytosis Plasma Properties Protein Transport - physiology Proteins Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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