The substitution V379I in PA protein attenuates the pathogenicity of influenza A（H1N1） pdm09 viruses in mice

Dear Editor,Since August 2010,the world was in the post-pandemic period and the influenza A（H1N1）pdm09（pdmH1N1）virus co-circulated with H3N2 and B virus seasonally（WHO,2010）.The continuous surveillance on the pdmH1N1 virus in the post-pandemic period was recommended by WHO.In order to detect unusual...

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Published in:中国科学：生命科学英文版 2017, Vol.60 (9), p.1044-1046
Main Author: Yongkun Chen Wenfei Zhu Tian Bai Xiaohui Zou Siyu Zhang Yan Sun Xiyan Li XingyYu Xiang Qinglong Zhao Chaoyang Huang Tao Chen Dayan Wang Yuelong Shu
Format: Article
Language:English
Subjects:
A蛋白
B病毒
住院病人
小鼠
流感
流行季节
甲型
致病性
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Summary:Dear Editor,Since August 2010,the world was in the post-pandemic period and the influenza A（H1N1）pdm09（pdmH1N1）virus co-circulated with H3N2 and B virus seasonally（WHO,2010）.The continuous surveillance on the pdmH1N1 virus in the post-pandemic period was recommended by WHO.In order to detect unusual events that might indicate a shift in severity disease,or emergence of a new virus,we collected a total of 312 throat swabs of laboratory-confirmed pdmHlNl patients from Hunan and Jilin provinces in China during January to March, 2016. Amongst them, 212 were influenza-like illness （ILI） outpatients while the remaining 100 were hospitalized patients.
ISSN:1674-7305
1869-1889