Low generational polyamidoamine dendrimers to enhance the solubility of folic acid：A‘‘dendritic effect’’investigation

Low generational（G0–G2,G for generation） polyamidoamine（PAMAM） dendrimers were investigated as enhancers to improve the aqueous solubility of folic acid at pH 11 and pH 5.In these two cases,the solubility of folic acid increases with both the dendrimer concentration and generation.However,the solubi...

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Bibliographic Details
Published in:中国化学快报：英文版 2014 (5), p.815-818
Main Author: Yong Zhang Mei-Ying Xu Tie-Kun Jiang Wei-Zhe Huang Jiang-Yu Wu
Format: Article
Language:English
Subjects:
PAMAM
叶酸
树枝状聚合物
树突
水溶解度
聚合物浓度
聚酰胺胺
静电相互作用
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Summary:Low generational（G0–G2,G for generation） polyamidoamine（PAMAM） dendrimers were investigated as enhancers to improve the aqueous solubility of folic acid at pH 11 and pH 5.In these two cases,the solubility of folic acid increases with both the dendrimer concentration and generation.However,the solubilization mechanism is different.The electrostatic interaction between the primary amines of dendrimers and the ionized carboxylic groups of folic acid dominates the dissolution process at pH 11 while the increase of the solubility of folic acid at pH 5 is attributed to the hydrophobic encapsulation inside the dendrimer molecules.In addition,for comparison ethylenediamine was used as a small molecule control to examine the ‘‘dendritic effect＇＇ in the dendrimer-related solubilization process.Interestingly,PAMAM dendrimers exhibit,at pH 5,a significant superiority over ethylenediamine in enhancing solubility,whereas this ‘‘dendritic effect＇＇ cannot be observed under the basic condition.
ISSN:1001-8417
1878-5964