No association between polymorphisms and haplotypes of COLIA1 and COLIA2 genes and osteoporotic fracture in postmenopausal Chinese women

Aim： To study whether genetic polymorphisms of COL1A1 and COL1A2 genes affected the onset of fracture in postmenopausal Chinese women. Methods： SNPs in COL1A1 and COL1A2 genes were identified via direct sequencing in 32 unrelated postmenopausal Chinese women. Ten SNPs were genotyped in 1252 postmeno...

Full description

Saved in:
Bibliographic Details
Published in:中国药理学报：英文版 2011, Vol.32 (7), p.947-955
Main Author: Wei-wei HU Jin-wei HE HaoZHANG Chun WANG Jie-mei GU Hua YUE Yao-hua KE Yun-qiu HU Wen-zhen FU Miao LI Yu-juan LIU Zhen-lin ZHANG
Format: Article
Language:English
Subjects:
中国
基因分型
妇女
疏松性
绝经后
遗传多态性
骨折
骨质
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim： To study whether genetic polymorphisms of COL1A1 and COL1A2 genes affected the onset of fracture in postmenopausal Chinese women. Methods： SNPs in COL1A1 and COL1A2 genes were identified via direct sequencing in 32 unrelated postmenopausal Chinese women. Ten SNPs were genotyped in 1252 postmenopausal Chinese women. The associations were examined using both single-SNP and hapIotype tests using logistic regression. Results： Twenty four （4 novel） and 28 （7 novel） SNPs were identified in COL1A1 and COL1A2 gene, respectively. The distribution frequencies of 2 SNPs in COLIA1 （rs2075554 and rs2586494） and 3 SNPs in COLIA2 （rs42517, rs1801182, and rs42524） were significantly different from those documented for the European Caucasian population. No significant difference was observed between fracture and control groups with respect to allele frequency or genotype distribution in 9 selected SNPs and haplotype. No significant association was found between fragility fracture and each SNP or haplotype. The results remained the same after additional corrections for other risk factors such as weight, height, and bone mineral density. Conclusion： Our results show no association between common genetic variations of COL1A1 and COL1A2 genes and fracture, suggesting the complex genetic background of osteoporotic fractures.
ISSN:1671-4083
1745-7254