Intracellular signaling pathways of ErbB2/HER-2 and family members

ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has b...

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Bibliographic Details
Published in:Breast cancer research : BCR 2001-12, Vol.3 (1), p.385-389, Article 385
Main Author: Olayioye, Monilola A
Format: Article
Language:English
Subjects:
Cellular signal transduction
Epidermal growth factor
Phosphotransferases
Tyrosine
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Summary:ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in many types of human cancers and is associated with poor clinical prognosis. Owing to the importance of ErbB proteins in both development and cellular transformation, a lot of attention has been drawn to the intracellular signals initiated by the engagement of this family of receptor tyrosine kinases. This review will focus on the membrane proximal events triggered by the ErbB receptor network and will address questions of how receptor heterodimerization may contribute to signal specification and diversification. Keywords: breast cancer, epidermal growth factor receptor, ErbB2/Neu/Her2, signal transduction, tyrosine phosphorylation
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr327