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Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases)
BACKGROUND: First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester. AIMS: In this study an evaluati...
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Published in: | Indian journal of human genetics 2006-01, Vol.11 (2) |
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Summary: | BACKGROUND: First trimester pregnancy loss is a very common
complication and a matter of concern for couples planning pregnancy.
Balanced chromosomal rearrangements in either parent is an important
cause of recurrent pregnancy loss particularly in the first trimester.
AIMS: In this study an evaluation of the contribution of chromosomal
anomalies in causing repeated spontaneous abortions was made. METHODS
AND MATERIALS: A review of the cytogenetic data in 742 couples (1484
individuals) with recurrent spontaneous abortions who were examined for
chromosomal aberrations in the period 1990-2003 is presented. Women who
had at least two abortions, or spontaneous abortions preceded or
followed by fetal deaths or birth of a malformed child, and patients
who had recurrent spontaneous abortions (> 3) with normal live
issue/s were studied. RESULTS: Chromosomal rearrangements were found
in 31 individuals (2%). These abnormalities included 22 (2.9%)
structural aberrations, 9 (1.2%) numerical anomalies. In addition to
these abnormalities, 21 (3.2%) chromosomal variants were also found.
CONCLUSION: Chromosomal analysis is an important etiological
investigation in couples with repeated spontaneous abortions as it
helps in genetic counseling and deciding about further reproductive
options. |
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ISSN: | 0971-6866 1998-362X |