Process Intensification of the Suzuki–Miyaura Reaction over Sol–Gel Entrapped Catalyst SiliaCat DPP-Pd Under Conditions of Continuous Flow

We report the newly developed conditions for the process intensification of the Suzuki–Miyaura reaction under flow over sol–gel entrapped SiliaCat DPP-Pd catalyst with the aim of practical applications. Considerably more concentrated solutions (0.5–1.0 M) are applied, and flow rate is increased up t...

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Bibliographic Details
Published in:Organic process research & development 2014-11, Vol.18 (11), p.1550-1555
Main Authors: Pandarus, Valerica, Gingras, Geneviève, Béland, François, Ciriminna, Rosaria, Pagliaro, Mario
Format: Article
Language:English
Online Access:Get full text
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Summary:We report the newly developed conditions for the process intensification of the Suzuki–Miyaura reaction under flow over sol–gel entrapped SiliaCat DPP-Pd catalyst with the aim of practical applications. Considerably more concentrated solutions (0.5–1.0 M) are applied, and flow rate is increased up to the practically relevant 1.0 mL/min threshold. Results indicate complete coupling conversion of several different aryl halides and provide important information of general validity of vital importance for successful process intensification.
ISSN:1083-6160
1520-586X
DOI:10.1021/op4003449