Structure-function relationship of heart valves in health and disease

The heart valves allow unidirectional and unobstructed passage of blood without regurgitation, trauma to blood elements, thromboembolism, and excessive stress concentrations in the leaflet and supporting tissue. In order to achieve this, the heart valves rely of their unique macroscale anatomy, hist...

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Main Author:	Sotiris Korossis
Format:	Default Book chapter
Published:	2018
Subjects:	Mechanical engineering not elsewhere classified Heart valves Histoarchitecture Biochemistry Biomechanics Structure-function Mechanical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/37026
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id	rr-article-9578315
record_format	Figshare
spelling	rr-article-95783152018-01-01T00:00:00Z Structure-function relationship of heart valves in health and disease Sotiris Korossis (5214488) Mechanical engineering not elsewhere classified Heart valves Histoarchitecture Biochemistry Biomechanics Structure-function Mechanical Engineering not elsewhere classified The heart valves allow unidirectional and unobstructed passage of blood without regurgitation, trauma to blood elements, thromboembolism, and excessive stress concentrations in the leaflet and supporting tissue. In order to achieve this, the heart valves rely of their unique macroscale anatomy, histoarchitecture and ultrastructural features that allow them to accommodate repetitive changes in shape and dimension throughout the cardiac cycle. This chapter is focused on the structure-function relationship of the heart valves, with particular focus on the aortic and mitral valves, discussing how the biochemical, histoarchitectural and anatomical features influence valvular function during the cardiac cycle and how valvular function dictates valvular architecture and ECM constitution. The chapter examines the structure-function relationship of valvular tissue by correlating its microscale histoarchitecture and biochemical constitution to its mesoscale biomechanics and macroscale function during the cardiac cycle. Moreover, the chapter examines the influence of pathological alterations on the histoarchitectural and biochemical characteristics of the valves on their biomechanical behavior. 2018-01-01T00:00:00Z Text Chapter 2134/37026 https://figshare.com/articles/chapter/Structure-function_relationship_of_heart_valves_in_health_and_disease/9578315 CC BY 3.0
institution	Loughborough University
collection	Figshare
topic	Mechanical engineering not elsewhere classified Heart valves Histoarchitecture Biochemistry Biomechanics Structure-function Mechanical Engineering not elsewhere classified
spellingShingle	Mechanical engineering not elsewhere classified Heart valves Histoarchitecture Biochemistry Biomechanics Structure-function Mechanical Engineering not elsewhere classified Sotiris Korossis Structure-function relationship of heart valves in health and disease
description	The heart valves allow unidirectional and unobstructed passage of blood without regurgitation, trauma to blood elements, thromboembolism, and excessive stress concentrations in the leaflet and supporting tissue. In order to achieve this, the heart valves rely of their unique macroscale anatomy, histoarchitecture and ultrastructural features that allow them to accommodate repetitive changes in shape and dimension throughout the cardiac cycle. This chapter is focused on the structure-function relationship of the heart valves, with particular focus on the aortic and mitral valves, discussing how the biochemical, histoarchitectural and anatomical features influence valvular function during the cardiac cycle and how valvular function dictates valvular architecture and ECM constitution. The chapter examines the structure-function relationship of valvular tissue by correlating its microscale histoarchitecture and biochemical constitution to its mesoscale biomechanics and macroscale function during the cardiac cycle. Moreover, the chapter examines the influence of pathological alterations on the histoarchitectural and biochemical characteristics of the valves on their biomechanical behavior.
format	Default Book chapter
author	Sotiris Korossis
author_facet	Sotiris Korossis
author_sort	Sotiris Korossis (5214488)
title	Structure-function relationship of heart valves in health and disease
title_short	Structure-function relationship of heart valves in health and disease
title_full	Structure-function relationship of heart valves in health and disease
title_fullStr	Structure-function relationship of heart valves in health and disease
title_full_unstemmed	Structure-function relationship of heart valves in health and disease
title_sort	structure-function relationship of heart valves in health and disease
publishDate	2018
url	https://hdl.handle.net/2134/37026
_version_	1797732828881879040

Structure-function relationship of heart valves in health and disease

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