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Biomarkers to identify and isolate senescent cells.
Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction. These cells can negatively affect neighbouring cells through an altered secretory phenotype: the senescence-associated secret...
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| Main Authors: | , , , |
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| Format: | Default Article |
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2016
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| Online Access: | https://hdl.handle.net/2134/21676 |
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| _version_ | 1805991506791628800 |
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| author | Mantas Matjusaitis Greg Chin Ethan Anders Sarnoski Alexandra Stolzing |
| author_facet | Mantas Matjusaitis Greg Chin Ethan Anders Sarnoski Alexandra Stolzing |
| author_sort | Mantas Matjusaitis (3946805) |
| collection | Figshare |
| description | Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction. These cells can negatively affect neighbouring cells through an altered secretory phenotype: the senescence-associated secretory phenotype (SASP). The SASP induces senescence in healthy cells, promotes tumour formation and progression, and contributes to other age-related diseases such as atherosclerosis, immune-senescence and neurodegeneration. Removal of senescent cells was recently demonstrated to delay age-related degeneration and extend lifespan. To better understand cell aging and to reap the benefits of senescent cell removal, it is necessary to have a reliable biomarker to identify these cells. Following an introduction to cellular senescence, we discuss several classes of biomarkers in the context of their utility in identifying and/or removing senescent cells from tissues. Although senescence can be induced by a variety of stimuli, senescent cells share some characteristics that enable their identification both in vitro and in vivo. Nevertheless, it may prove difficult to identify a single biomarker capable of distinguishing senescence in all cell types. Therefore, this will not be a comprehensive review of all senescence biomarkers but rather an outlook on technologies and markers that are most suitable to identify and isolate senescent cells. |
| format | Default Article |
| id | rr-article-9575819 |
| institution | Loughborough University |
| publishDate | 2016 |
| record_format | Figshare |
| spelling | rr-article-95758192016-01-01T00:00:00Z Biomarkers to identify and isolate senescent cells. Mantas Matjusaitis (3946805) Greg Chin (7215458) Ethan Anders Sarnoski (7215461) Alexandra Stolzing (1251348) Mechanical engineering not elsewhere classified Senescence Biomarkers Cell biology Mechanical Engineering not elsewhere classified Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction. These cells can negatively affect neighbouring cells through an altered secretory phenotype: the senescence-associated secretory phenotype (SASP). The SASP induces senescence in healthy cells, promotes tumour formation and progression, and contributes to other age-related diseases such as atherosclerosis, immune-senescence and neurodegeneration. Removal of senescent cells was recently demonstrated to delay age-related degeneration and extend lifespan. To better understand cell aging and to reap the benefits of senescent cell removal, it is necessary to have a reliable biomarker to identify these cells. Following an introduction to cellular senescence, we discuss several classes of biomarkers in the context of their utility in identifying and/or removing senescent cells from tissues. Although senescence can be induced by a variety of stimuli, senescent cells share some characteristics that enable their identification both in vitro and in vivo. Nevertheless, it may prove difficult to identify a single biomarker capable of distinguishing senescence in all cell types. Therefore, this will not be a comprehensive review of all senescence biomarkers but rather an outlook on technologies and markers that are most suitable to identify and isolate senescent cells. 2016-01-01T00:00:00Z Text Journal contribution 2134/21676 https://figshare.com/articles/journal_contribution/Biomarkers_to_identify_and_isolate_senescent_cells_/9575819 CC BY-NC-ND 4.0 |
| spellingShingle | Mechanical engineering not elsewhere classified Senescence Biomarkers Cell biology Mechanical Engineering not elsewhere classified Mantas Matjusaitis Greg Chin Ethan Anders Sarnoski Alexandra Stolzing Biomarkers to identify and isolate senescent cells. |
| title | Biomarkers to identify and isolate senescent cells. |
| title_full | Biomarkers to identify and isolate senescent cells. |
| title_fullStr | Biomarkers to identify and isolate senescent cells. |
| title_full_unstemmed | Biomarkers to identify and isolate senescent cells. |
| title_short | Biomarkers to identify and isolate senescent cells. |
| title_sort | biomarkers to identify and isolate senescent cells. |
| topic | Mechanical engineering not elsewhere classified Senescence Biomarkers Cell biology Mechanical Engineering not elsewhere classified |
| url | https://hdl.handle.net/2134/21676 |