Bistable epigenetic states explain age-dependent decline in mesenchymal stem cell heterogeneity
The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (Sca-1) in mouse bone marrow Mesenchymal Stem Cell (MSC) clones. We show that subpopulations with varying Sca-1 express...
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Main Authors: | Zahia Hamidouche, Karen Rother, Jens Przybilla, Axel Krinner, Dennis Clay, Lydia Hopp, Claire Fabian, Alexandra Stolzing, Hans Binder, Pierre Charbord, Joerg Galle |
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Format: | Default Article |
Published: |
2016
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Subjects: | |
Online Access: | https://hdl.handle.net/2134/23042 |
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