Bistable epigenetic states explain age-dependent decline in mesenchymal stem cell heterogeneity

Bistable epigenetic states explain age-dependent decline in mesenchymal stem cell heterogeneity

The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (Sca-1) in mouse bone marrow Mesenchymal Stem Cell (MSC) clones. We show that subpopulations with varying Sca-1 express...

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Bibliographic Details
Main Authors: Zahia Hamidouche, Karen Rother, Jens Przybilla, Axel Krinner, Dennis Clay, Lydia Hopp, Claire Fabian, Alexandra Stolzing, Hans Binder, Pierre Charbord, Joerg Galle
Format: Default Article
Published: 2016
Subjects:
Mechanical engineering not elsewhere classified
FACS
Aging
Epigenetics
Mesenchymal stem cells
Methylation
Mechanical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/23042
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https://hdl.handle.net/2134/23042

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